Seguin is strategically located in South Central Texas on Interstate Highway 10. Thirty minutes east of San Antonio, the tenth largest city in the United States. Austin, the state capital, is conveniently accessible 50 miles to the north by State Highway 123 and Interstate Highway 35. The ports of Houston and Corpus Christi are nearly equal distance from Seguin.

Seguin is home to Texas Lutheran University and several industries, including Alamo Industrial, SMI Steel, Hexcel and Motorola.
The average annual temperature is 67 degrees and the annual average precipitation is 31.9 inches.